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Related Concept Videos

Skin Diseases and Disorders01:23

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Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
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Hypersensitivities01:30

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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
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Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
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Atopic Dermatitis Disease Complications.

Alyssa G Ashbaugh1, Shawn G Kwatra2

  • 1Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Advances in Experimental Medicine and Biology
|October 25, 2017
PubMed
Summary
This summary is machine-generated.

Atopic dermatitis (AD) increases susceptibility to bacterial, viral, and fungal infections due to immune issues and skin barrier defects. Environmental factors and treatments can also trigger flares and lead to serious health conditions.

Keywords:
ComplicationsEnvironmental triggersImmunological dysregulationInfectionTreatment complications

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Area of Science:

  • Dermatology
  • Immunology
  • Infectious Diseases

Background:

  • Atopic dermatitis (AD) is a chronic inflammatory skin condition.
  • It is characterized by immune dysregulation and impaired skin barrier function.
  • These factors predispose individuals to infections and disease flares.

Purpose of the Study:

  • To review infectious complications associated with atopic dermatitis.
  • To explore the relationship between atopic dermatitis and infectious diseases.
  • To discuss environmental triggers, treatment complications, and associated serious conditions.

Main Methods:

  • Literature review of infectious complications in atopic dermatitis.
  • Analysis of immunological dysregulation and skin barrier defects.
  • Examination of environmental triggers and treatment-related issues.

Main Results:

  • Atopic dermatitis patients face increased risk of bacterial, viral, and fungal infections.
  • Immune dysfunction and poor skin barrier function are key contributors.
  • Environmental agents and treatments can exacerbate atopic dermatitis and lead to complications.

Conclusions:

  • Understanding the interplay between atopic dermatitis, infections, and environmental factors is crucial.
  • Management should address infectious risks and potential treatment complications.
  • Association with serious conditions like lymphoma warrants further investigation.