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Atopic Dermatitis Disease Complications

Alyssa G Ashbaugh1, Shawn G Kwatra2

  • 1Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Advances in Experimental Medicine and Biology
|October 25, 2017
PubMed

Insights

Atopic dermatitis (AD) increases susceptibility to bacterial, viral, and fungal infections due to immune issues and skin barrier defects. Environmental factors and treatments can also trigger flares and lead to serious health conditions.

Area of Science:

  • Dermatology
  • Immunology
  • Infectious Diseases

Background:

  • Atopic dermatitis (AD) is a chronic inflammatory skin condition.
  • It is characterized by immune dysregulation and impaired skin barrier function.
  • These factors predispose individuals to infections and disease flares.

Purpose of the Study:

  • To review infectious complications associated with atopic dermatitis.
  • To explore the relationship between atopic dermatitis and infectious diseases.
  • To discuss environmental triggers, treatment complications, and associated serious conditions.

Main Methods:

  • Literature review of infectious complications in atopic dermatitis.
  • Analysis of immunological dysregulation and skin barrier defects.
  • Examination of environmental triggers and treatment-related issues.

Main Results:

  • Atopic dermatitis patients face increased risk of bacterial, viral, and fungal infections.
  • Immune dysfunction and poor skin barrier function are key contributors.
  • Environmental agents and treatments can exacerbate atopic dermatitis and lead to complications.

Conclusions:

  • Understanding the interplay between atopic dermatitis, infections, and environmental factors is crucial.
  • Management should address infectious risks and potential treatment complications.
  • Association with serious conditions like lymphoma warrants further investigation.
Keywords:
ComplicationsEnvironmental triggersImmunological dysregulationInfectionTreatment complications

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