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Chromophore decomposition in multispectral time-resolved diffuse optical tomography.
Judy Zouaoui1, Laura Di Sieno2, Lionel Hervé1
1Univ. Grenoble Alpes, F-38000 Grenoble, France, CEA, LETI, MINATEC Campus, F-38054 Grenoble, France.
Biomedical Optics Express
|October 31, 2017
Summary
Multispectral diffuse optical tomography can locate small objects in turbid media. However, accurately determining their exact material composition without prior information remains a challenge.
Area of Science:
- Biomedical Optics
- Medical Imaging
- Photonics
Background:
- Diffuse optical tomography (DOT) is a non-invasive imaging technique.
- Accurate quantification of tissue properties is crucial for diagnostic applications.
Purpose of the Study:
- To assess multispectral time domain diffuse optical tomography (TD-DOT) in reflectance mode.
- To evaluate its capability in quantifying position and composition of small heterogeneities.
- To determine imaging performance at depths of 1-1.5 cm in scattering media.
Main Methods:
- Utilized multicomponent phantoms with known optical properties.
- Employed time-resolved data acquisition in reflectance geometry.
- Analyzed time-resolved data using the Mellin-Laplace transform for inverse problem solving.
Main Results:
- Demonstrated good spatial localization accuracy for embedded heterogeneities.
- Showed correct qualitative assessment of compositional changes (gradation).
- Observed limitations in achieving absolute material composition accuracy without prior geometric information.
Conclusions:
- TD-DOT in reflectance mode shows promise for detecting and localizing subsurface anomalies.
- Further advancements are needed to improve absolute compositional quantification in unknown geometries.
- This technique holds potential for applications requiring detection of localized changes in scattering media.
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