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Updated: Feb 18, 2026
09:43
Simplified Human Neutrophil Extracellular Traps NETs Isolation and Handling
Published on: April 16, 2015
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Re-cyclin' Cell-Cycle Components to Make NETs.
Jean Albrengues1, Robert W Wysocki2, Laura Maiorino3
1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
Developmental Cell
|November 22, 2017
Summary
Neutrophil extracellular traps (NETs) are crucial for fighting pathogens but also linked to diseases. A new study reveals that terminally differentiated neutrophils reuse cell-cycle proteins to create these traps.
Area of Science:
- Immunology
- Cell Biology
Background:
- Neutrophil extracellular traps (NETs) are essential for host defense against pathogens.
- NET formation is also implicated in inflammatory diseases, thrombosis, and cancer.
Purpose of the Study:
- To investigate the molecular mechanisms underlying NET formation in terminally differentiated neutrophils.
Main Methods:
- Analysis of gene expression and protein localization in neutrophils.
- Functional assays to assess NET formation.
Main Results:
- Terminally differentiated, non-cycling neutrophils utilize cell-cycle proteins and pathways for NET formation.
- Repurposing of cell-cycle machinery contributes to the functional plasticity of neutrophils.
Conclusions:
- Neutrophils exhibit remarkable adaptability by repurposing existing cellular pathways for specialized functions like NETosis.
- Understanding these mechanisms could offer new therapeutic targets for NET-associated diseases.
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