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Mitochondrial DNA in Telocytes.

Dongli Song1,2, Dragos Cretoiu3,4, Xiangdong Wang5

  • 1Zhongshan Hospital Institute of Clinical Science, Fudan University, Shanghai Medical College, Shanghai, China.

Advances in Experimental Medicine and Biology
|November 28, 2017
PubMed
Summary
This summary is machine-generated.

Telocytes (TCs) are novel interstitial cells found in mammals. This review explores TC and TC mitochondria functions, highlighting potential roles of mitochondrial DNA (mtDNA) in TCs.

Keywords:
DNAMitochondriaTelocytes

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Area of Science:

  • Cell Biology
  • Histology
  • Mitochondrial Biology

Background:

  • Telocytes (TCs) are a recently identified interstitial cell type present in various mammalian tissues.
  • TCs possess unique ultrastructural features, including a small nucleus and long, thin prolongations.
  • These cells are implicated in numerous physiological and pathological processes.

Purpose of the Study:

  • To provide a comprehensive overview of telocytes (TCs), including their origin, distribution, morphology, and functions.
  • To review the distribution and functions of mitochondria within TCs.
  • To explore the potential roles and significance of mitochondrial DNA (mtDNA) within TCs.

Main Methods:

  • Literature review of existing studies on telocytes and their mitochondria.
  • Analysis of ultrastructural observations of mitochondria in TCs, particularly in inflammatory conditions.
  • Synthesis of current knowledge on mitochondrial DNA (mtDNA) functions.

Main Results:

  • Telocytes are widely distributed across mammalian species and play crucial roles in tissue homeostasis and disease.
  • Mitochondria within TCs exhibit specific ultrastructural characteristics and can undergo alterations, as observed in inflammatory ureter tissue.
  • Mitochondrial DNA (mtDNA) is fundamental for mitochondrial function and is involved in various biological processes.

Conclusions:

  • A deeper understanding of TC mitochondria and mtDNA is essential for elucidating their full functional significance.
  • Investigating mtDNA in TCs may reveal novel insights into TC-mediated physiological and pathological mechanisms.
  • This review aims to consolidate current knowledge and guide future research on telocytes and their mitochondrial components.