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Updated: Feb 17, 2026
Modified Single-Loop Reconstruction for Pancreaticoduodenectomy
Published on: September 28, 2019
Rare, Uncommon, and Unusual Complications After Pancreaticoduodenal Resection
Thinzar M Lwin1, Natasha Leigh2, Mazen E Iskandar3
1Department of Surgery, University of California San Diego, 3855 Health Sciences Drive, La Jolla, CA 92093, USA; Department of Surgery, Mt Sinai Beth Israel, 10 Nathan D Perlman Place, New York, NY 10003, USA.
Abstract:
Complications after pancreaticoduodenal resection occur in at least 30% of patients. Most are a direct result of an intraoperative event, dissection, or anastomoses which account for the most serious morbidities, sepsis, pseudoaneurysms, and hemorrhage. Rarely, complications are due to the systemic impact of the procedure even if the procedure itself was unremarkable. Rare systemic complications after PDR (Transfusion transmitted Babesiosis, pituitary apoplexy, and TRALI) and a number of uncommon and unusual other complications are discussed. Pancreaticoduodenal resection is a significant operation with serious consequences. Decisions on selection of candidates and safe operations should be thoughtful and always in surgeons' minds.
Insights
Pancreaticoduodenal resection (PDR) leads to complications in over 30% of patients, often due to surgical factors. Rare systemic effects, alongside common morbidities like sepsis, require careful surgical consideration.
Area of Science:
- Surgical Oncology
- Gastrointestinal Surgery
- Patient Safety
Background:
- Pancreaticoduodenal resection (PDR) is a major surgical procedure.
- Complications occur in at least 30% of patients undergoing PDR.
- Most complications stem from intraoperative events, dissection, or anastomoses.
Purpose of the Study:
- To discuss the spectrum of complications following pancreaticoduodenal resection.
- To highlight both common and rare systemic complications.
- To emphasize the importance of careful candidate selection and surgical technique.
Main Methods:
- Review of literature and clinical experience regarding PDR complications.
- Discussion of common morbidities (sepsis, pseudoaneurysms, hemorrhage).
- Exploration of rare systemic complications (e.g., Transfusion Transmitted Babesiosis, pituitary apoplexy, TRALI).
Main Results:
- Common complications are directly related to surgical manipulation and anastomoses.
- Rare systemic complications can occur even after an uncomplicated procedure.
- The overall incidence of complications is significant, impacting patient outcomes.
Conclusions:
- Pancreaticoduodenal resection is associated with substantial morbidity.
- Understanding and anticipating both common and rare complications is crucial.
- Thoughtful candidate selection and meticulous surgical execution are paramount for patient safety.
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