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Organizing Organoids: Stem Cells Branch Out.

Jamie A Davies1

  • 1Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK.

Cell Stem Cell
|December 9, 2017
PubMed
Summary

Researchers developed a method to create branch-competent ureteric buds from stem cells. This breakthrough advances kidney organoid development and understanding of kidney embryology.

Area of Science:

  • Developmental biology
  • Stem cell research
  • Regenerative medicine

Background:

  • Kidney development relies on the ureteric bud, a complex epithelial structure.
  • Generating functional kidney tissues in vitro is crucial for disease modeling and transplantation.
  • Previous methods struggled to produce branch-competent ureteric buds essential for kidney morphogenesis.

Purpose of the Study:

  • To establish an optimized protocol for generating branch-competent ureteric buds.
  • To utilize both mouse embryonic stem cells and human induced pluripotent stem cells.
  • To advance the creation of more accurate kidney organoids.

Main Methods:

  • Optimized differentiation protocols for mouse embryonic stem cells and human induced pluripotent stem cells.

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  • Induction of specific signaling pathways to guide ureteric bud formation.
  • Assessment of branching morphogenesis in vitro.

    • Main Results:

    • Successfully generated branch-competent ureteric buds from both cell types.
    • The generated structures exhibited key characteristics of in vivo ureteric buds.
    • The method provides a robust system for studying kidney development.

    Conclusions:

    • The optimized method enables the efficient production of key kidney developmental structures from pluripotent stem cells.
    • This work significantly improves the potential for creating advanced kidney organoids.
    • The findings offer new insights into the fundamental processes of kidney embryology.