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Rodent Model of Intestinal Ischemia-Reperfusion Injury via Occlusion of the Superior Mesenteric Artery
Published on: October 20, 2023
Mesenteric Ischemia
1Academic Programs, The University of Alabama, Capstone College of Nursing, 650 University Boulevard, East, Tuscaloosa, AL 35401, USA.
Abstract:
Mesenteric ischemia is an uncommon disease most often seen in the elderly. This disease results from blood flow in the mesenteric circulation that inadequately meets metabolic needs of the visceral organs and, if untreated, eventually leads to necrosis of the bowel wall. Mesenteric ischemia is divided into 2 types: acute mesenteric ischemia (AMI) and chronic mesenteric ischemia (CMI). Delayed diagnosis of CMI can lead to AMI. AMI is associated with extremely high mortalities. Early diagnosis via computed tomography angiography and prompt revascularization via endovascular therapy are recommended for symptomatic patients who have not developed bowel ischemia and necrosis.
Insights
Mesenteric ischemia, a condition of inadequate blood flow to the intestines, can lead to bowel necrosis. Early diagnosis with CT angiography and endovascular therapy are crucial for treating acute mesenteric ischemia (AMI).
Area of Science:
- Vascular Surgery
- Gastroenterology
- Radiology
Background:
- Mesenteric ischemia is a rare condition, primarily affecting the elderly.
- It stems from insufficient blood flow in the mesenteric circulation, potentially causing bowel necrosis.
- Mesenteric ischemia is classified into acute (AMI) and chronic (CMI) types, with delayed CMI diagnosis risking progression to AMI.
Purpose of the Study:
- To summarize the pathophysiology and clinical presentation of mesenteric ischemia.
- To highlight the diagnostic and therapeutic recommendations for acute mesenteric ischemia.
Main Methods:
- Literature review of mesenteric ischemia, focusing on diagnosis and treatment.
- Emphasis on computed tomography angiography (CTA) for early detection.
- Discussion of endovascular therapy as a primary treatment modality.
Main Results:
- Acute mesenteric ischemia (AMI) carries a high mortality rate.
- Delayed diagnosis of chronic mesenteric ischemia (CMI) can precipitate AMI.
- Computed tomography angiography (CTA) enables early diagnosis.
- Endovascular therapy offers prompt revascularization.
Conclusions:
- Early diagnosis of mesenteric ischemia is critical.
- Computed tomography angiography (CTA) is the recommended diagnostic tool.
- Endovascular therapy is advised for symptomatic patients without bowel necrosis to prevent mortality.
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