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Toxicogenomics: A New Paradigm for Nanotoxicity Evaluation.
Sourabh Dwivedi1, Quaiser Saquib2, Bilal Ahmad3
1Department of Applied Physics, Faculty of Engineering and Technology, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
Advances in Experimental Medicine and Biology
|February 18, 2018
Summary
Nanoparticle (NP) applications raise toxicity concerns. Toxicogenomics and genomic approaches reveal molecular mechanisms of NP toxicity in various test models.
Area of Science:
- Nanotoxicology
- Genomics
- Molecular Toxicology
Background:
- Widespread nanoparticle (NP) applications raise global concerns regarding potential toxicity to humans and organisms.
- NP aggregation and accumulation within cells can lead to interactions with macromolecules, inducing toxicological effects.
- Understanding these effects is crucial for assessing environmental and health risks.
Purpose of the Study:
- To explore the toxicological responses of nanoparticles (NPs).
- To provide a clear understanding of the molecular mechanisms underlying NP-induced toxicity.
- To highlight the role of toxicogenomics in nanotoxicology research.
Main Methods:
- Application of toxicogenomics to investigate molecular pathway-based toxicological consequences.
- Utilizing genomic approaches for molecular-level insights.
- Discussion of toxicological responses in both in vivo and in vitro test models.
Main Results:
- Genomic approaches offer a powerful tool for identifying and quantifying global gene expression shifts.
- Toxicogenomics opens new avenues for nanotoxicology research by elucidating molecular pathways.
- The study discusses NP toxicological responses across different experimental models.
Conclusions:
- Nanoparticle toxicity is a significant concern requiring detailed molecular investigation.
- Genomic and toxicogenomic methods are essential for understanding NP-induced toxicity mechanisms.
- Further research using these approaches is vital for safe NP application.
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