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Updated: Feb 13, 2026
07:07
Determining Glucose Metabolism Kinetics Using 18F-FDG Micro-PET/CT
Published on: May 2, 2017
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18F-FDG PET/CT in splenic marginal zone lymphoma
Domenico Albano1, Raffaele Giubbini2, Francesco Bertagna2
1Nuclear Medicine, University of Brescia and Spedali Civili Brescia, P.le Spedali Civili 1, 25123, Brescia, Italy. doalba87@libero.it.
Abdominal Radiology (New York)
|March 4, 2018
Summary
76% of splenic marginal zone lymphoma (SMZL) cases showed 18F-FDG avidity, primarily with diffuse splenic uptake. This FDG avidity correlated only with the Ki-67 index, not other clinical features.
Area of Science:
- Oncology
- Nuclear Medicine
- Radiology
Background:
- Splenic marginal zone lymphoma (SMZL) is a rare non-Hodgkin lymphoma.
- The metabolic behavior and detection rates of 18F-FDG PET/CT in SMZL require further clarification.
Purpose of the Study:
- To investigate the metabolic behavior of SMZL using 18F-FDG PET/CT.
- To determine if tumor stage, epidemiological, histological, or morphological features correlate with 18F-FDG PET/CT results in SMZL.
Main Methods:
- Fifty-one patients with histologically confirmed SMZL underwent initial staging with 18F-FDG PET/CT.
- PET/CT images were analyzed visually and semi-quantitatively (SUVmax, lesion-to-liver SUVmax ratio, lesion-to-blood pool SUVmax ratio).
- Splenic uptake was categorized as diffuse or focal.
Main Results:
- 76% of SMZL patients (39/51) exhibited 18F-FDG avidity, with diffuse splenic uptake being the most common pattern.
- In FDG-avid cases, average SUVmax was 4.3, lesion-to-liver SUVmax ratio was 2.3, and lesion-to-blood pool SUVmax ratio was 3.
- 18F-FDG avidity significantly correlated with the Ki-67 index but not with other clinical, histological, or morphological features. Semiquantitative parameters did not correlate with any variable.
Conclusions:
- 18F-FDG avidity is present in a majority of SMZL cases, predominantly with diffuse splenic uptake.
- The Ki-67 index is the sole feature correlated with 18F-FDG avidity in SMZL.
- 18F-FDG PET/CT findings did not influence progression-free survival in this cohort.
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