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Updated: Feb 13, 2026

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Restraint to Induce Stress in Mice and Rats
Published on: December 6, 2024
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EXPRESSION OF REG1Α, GAST AND TGFB1 GENES IN CONDITIONS OF STRESSINDUCED GASTRIC MUCOUS LESIONS DEVELOPMENT AND
Summary
Reg1a gene expression increases during stress-induced gastric lesions but decreases after stress cessation. Transforming growth factor beta 1 (Tgfb1) may aid in healing these stress-induced gastric lesions.
Area of Science:
- Gastroenterology
- Molecular Biology
- Stress Physiology
Background:
- Stress-induced gastric lesions are a significant clinical concern.
- Understanding the molecular mechanisms of gastric lesion development and healing is crucial.
Purpose of the Study:
- To analyze Reg1a gene expression in rat gastric mucosa during stress-induced lesion development and healing.
- To investigate the role of gastrin and Tgfb1 in Reg1a gene regulation under stress.
Main Methods:
- Quantitative analysis of Reg1a and Gast gene expression in rat gastric mucosa.
- Assessment of lipid peroxidation and antioxidant system function.
- Correlation analysis between Reg1a and Tgfb1 gene expression.
Main Results:
- Reg1a gene expression significantly increased during stress exposure, peaking at 3 hours.
- Reg1a expression sharply decreased after stressor termination.
- Gastrin did not stimulate Reg1a expression under water immersion restraint stress.
- A positive correlation was found between Reg1a and Tgfb1 gene expression during lesion healing.
Conclusions:
- Reg1a gene expression is dynamically regulated during stress-induced gastric injury and recovery.
- Tgfb1 may play a role in accelerating the healing of stress-induced gastric lesions.
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