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Updated: Feb 13, 2026
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Organotypic Cultures of Adult Human Cortex as an Ex vivo Model for Human Stem Cell Transplantation and Validation
Published on: December 9, 2022
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Adult Stem Cells and Medicine
Sinem Civriz Bozdağ1, Meltem Kurt Yüksel1, Taner Demirer2
1Department of Hematology, Ankara University Medical School, Ankara, Turkey.
Advances in Experimental Medicine and Biology
|March 21, 2018
Summary
Hematopoietic stem cells (HSCs) are crucial for blood cell formation and treating various diseases. Ongoing research explores innovative HSC therapies, including CAR-T cell treatments, for refractory hematologic malignancies and solid tumors.
Area of Science:
- Stem cell biology
- Hematology
- Immunotherapy
Background:
- Stem cells are classified by potency: totipotent, pluripotent, multipotent, and unipotent.
- Hematopoietic stem cells (HSCs) are the first identified adult stem cells (ASCs), originating all blood and immune cells.
- Hematopoietic stem cell transplantation (HSCT) is a pioneering cellular therapy for hematologic malignancies.
Purpose of the Study:
- To discuss the properties, niches, and clinical applications of HSCs.
- To highlight the rapid advancements in HSC research and innovative therapeutic approaches.
- To explore the future contributions of HSCs to modern medicine.
Main Methods:
- Review of existing literature on stem cell properties and classifications.
- Analysis of clinical applications of Hematopoietic stem cell transplantation (HSCT).
- Discussion of emerging innovative therapies like haploidentical HSCT and CAR-T cell therapies.
Main Results:
- HSCs are foundational for hematopoiesis and immune system development.
- HSCT is an established treatment for numerous hematological diseases, including leukemia and lymphoma.
- Novel HSC-based and related immunotherapies show promise for refractory diseases and solid tumors.
Conclusions:
- HSCs possess diverse properties and niches, enabling broad clinical applications.
- Advancements in HSCT and immunotherapy offer new hope for challenging hematologic conditions.
- Continued research into HSCs is vital for future medical breakthroughs and treatments.
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