Multidimensional Gas Chromatography for Chiral Analysis.

Area of Science:

• Analytical Chemistry
• Chromatography

Background:

• Multidimensional gas chromatography (MDGC) is a powerful separation technique.
• Enantioselective MDGC (enantio-MDGC) is preferred for resolving difficult enantiomer separations.
• Existing literature covers enantio-MDGC for PCBs, essential oils, flavors, fragrances, and amino acids.

Purpose of the Study:

• To review the applications of MDGC in chiral analysis.
• To present both heart-cutting GC-GC and comprehensive GC × GC techniques.
• To categorize applications based on compound type due to the broad scope.

Main Methods:

• Review of existing literature on MDGC and enantio-MDGC.
• Focus on heart-cutting (GC-GC) and comprehensive (GC × GC) multidimensional approaches.
• Categorization of applications by chemical compound class.

Main Results:

• MDGC, particularly enantio-MDGC, is effective for separating overlapping enantiomers.
• Applications span diverse fields including environmental analysis (PCBs) and natural products (essential oils, flavors, fragrances, amino acids).
• Both GC-GC and GC × GC are valuable MDGC strategies for chiral separations.

Conclusions:

• MDGC is a versatile and preferred method for enantioselective analysis.
• The review provides a structured overview of MDGC applications in chiral separations.
• Further research can benefit from this categorized summary of techniques and compound classes.