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Updated: Feb 12, 2026

Optimized Transfection Strategy for Expression and Electrophysiological Recording of Recombinant Voltage-Gated Ion Channels in HEK-293T Cells
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Optimized Transfection Strategy for Expression and Electrophysiological Recording of Recombinant Voltage-Gated Ion Channels in HEK-293T Cells

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Structure-Function Relationship of the Voltage-Gated Calcium Channel Cav1.1 Complex

Jianping Wu1,2, Nieng Yan1,2, Zhen Yan3,4

  • 1State Key Laboratory of Membrane Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences and School of Medicine, Tsinghua University, Beijing, China.

Advances in Experimental Medicine and Biology
|March 30, 2018
PubMed
Summary

Structural insights into voltage-gated calcium (Cav) channels reveal the mechanism of skeletal muscle excitation-contraction coupling. The Cav1.1 channel structure provides a template for understanding Cav and Nav channel function and disease.

Keywords:
Cav1.1DHPRStructureVoltage-gated calcium channel

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