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Sall1 Regulates Microglial Morphology Cell Autonomously in the Developing Retina

Hideto Koso1, Ryuichi Nishinakamura2, Sumiko Watanabe3

  • 1Division of Molecular and Developmental Biology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

Advances in Experimental Medicine and Biology
|May 4, 2018
PubMed
Summary

The Sall1 gene is crucial for microglial cell morphology during retinal development. Sall1 deficiency causes abnormal microglial shapes in developing retinas, confirming its cell-autonomous role.

Keywords:
Conditional knockout miceMicrogliaMicroglial developmentMicroglial morphologyRetinal degenerationRetinal developmentSall1Transcriptional factor

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