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Updated: Feb 11, 2026

Cryosectioning and Immunostaining of Mouse Retina
Published on: February 28, 2025
Impact of MCT1 Haploinsufficiency on the Mouse Retina
Neal S Peachey1,2,3, Minzhong Yu4,5, John Y S Han6
1Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA. neal.peachey@va.gov.
Abstract:
The monocarboxylate transporter 1 (MCT1) is highly expressed in the outer retina, suggesting that it plays a critical role in photoreceptors. We examined MCT1 +/- heterozygotes, which express half of the normal complement of MCT1. The MCT1 +/- retina developed normally and retained normal function, indicating that MCT1 is expressed at sufficient levels to support outer retinal metabolism.
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