PROGESTERONE RECEPTOR GENE POLYMORPHISMS AS GENETIC RISK FACTOR OF THREATENED ABORTION

Area of Science:

• Genetics
• Reproductive Medicine
• Molecular Biology

Background:

• Threatened abortion is a common complication of early pregnancy.
• Genetic factors are increasingly recognized as potential contributors to pregnancy loss.
• The progesterone receptor (PGR) plays a crucial role in maintaining pregnancy.

Purpose of the Study:

• To investigate the association between progesterone receptor gene polymorphisms (rs590688 and rs500760) and threatened abortion.
• To explore potential genetic precursors of threatened abortion.
• To assess ethnic differences in PGR gene variants.

Main Methods:

• Polymerase Chain Reaction (PCR) was used to determine genotypes.
• Genotyping was performed on 67 patients with threatened abortion and 93 healthy individuals.
• Statistical analysis (chi-squared test) was employed to compare allelic frequencies.

Main Results:

• The allelic distribution of the rs590688 polymorphism differed significantly between patients and controls (P<0.05).
• Specifically, the G/G genotype of rs590688 was found in 31.3% of patients versus 14.1% of controls.
• No statistically significant difference was observed for the rs500760 polymorphism between the groups (P>0.05).
• The G/G genotype of rs590688 was nearly 10 times higher in the study group compared to Taiwanese Han women with recurrent pregnancy loss, indicating ethnic variations.

Conclusions:

• The rs590688 polymorphism in the progesterone receptor gene is significantly associated with threatened abortion.
• The G/G genotype at rs590688 may represent a genetic risk factor for threatened abortion.
• Significant ethnic differences exist in PGR gene distribution, highlighting the clinical relevance of rs590688.