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Updated: Feb 9, 2026

Author Spotlight: Studying Behavior of Acanthamoeba to Develop Targeted Strategies for Preventing Acanthamoeba Keratitis
Published on: September 20, 2024
A report of 10 patients with Acanthamoeba keratitis
E A Alfonso-Muñoz1, M J Roig-Revert1, E Fernández-López1
1FISABIO-Oftalmología Médica (FOM), Unidad de Córnea y Enfermedades del Segmento Anterior, Valencia, España.
Clinical Cases:
Cases are presented of 10 patients with Acanthamoeba keratitis treated between 2008 and 2017. All were contact lens wearers. All of them received treatment with a biguanide combined with a diamidine. In 3 cases the infestation did not exceed the superficial stroma, responding to topical treatment. In 7, the infection reached the deep stroma, with 6 of these cases requiring penetrating keratoplasty (PKP), 3 of them therapeutic PKP because of perforation risk or ocular spreading. The visual acuity improved in all the cases.
Conclusion:
The infestation depth at the time of diagnosis appears to be the main risk factor for requiring a PKP.
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