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Updated: Feb 8, 2026

A Rapid Screening Workflow to Identify Potential Combination Therapy for GBM using Patient-Derived Glioma Stem Cells
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Gene Therapy and Virotherapy of Gliomas

Julius W Kim, Alan L Chang, J Robert Kane

    Progress in Neurological Surgery
    |July 11, 2018
    PubMed

    Insights

    Gene therapy and oncolytic virotherapy offer new hope for treating malignant brain tumors. These advanced strategies show promise for improving survival rates in patients with high-grade gliomas.

    Area of Science:

    • Neuro-oncology
    • Cancer Biology
    • Gene Therapy

    Background:

    • High-grade gliomas remain challenging to treat, with dismal patient survival rates despite current multimodal therapies.
    • Existing treatments like surgery, chemoradiotherapy, and targeted therapies have limited efficacy for advanced malignant brain tumors.
    • Understanding cancer biology and genetic modification techniques are advancing rapidly.

    Purpose of the Study:

    • To explore the potential of gene therapy and oncolytic virotherapy for malignant brain tumor treatment.
    • To highlight novel therapeutic strategies addressing the limitations of current glioma management.

    Main Methods:

    • Review of recent advances in gene therapy and oncolytic virotherapy.
    • Analysis of progress in understanding glioma biology.
    • Evaluation of improved techniques for genetic modification of therapeutic agents.

    Main Results:

    • Gene therapy and oncolytic virotherapy are emerging as highly promising treatment strategies.
    • These novel approaches leverage recent progress in cancer biology and genetic engineering.
    • Potential for improved outcomes in patients with malignant brain tumors.

    Conclusions:

    • Gene therapy and oncolytic virotherapy represent a significant advancement in neuro-oncology.
    • These strategies offer a promising future for managing high-grade gliomas and other malignant brain tumors.
    • Further research and development in these areas are warranted to improve patient survival.

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