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A Modified Method for Heterotopic Mouse Heart Transplantion
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A Modified Method for Heterotopic Mouse Heart Transplantion

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Heart Transplantation Survival and Sex-Related Differences

Martina Previato1, Elena Osto2,3,4, Peter L M Kerkhof5

  • 1Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padova, Italy.

Advances in Experimental Medicine and Biology
|July 28, 2018
PubMed

Insights

Orthotopic heart transplantation (OHT) offers improved survival for end-stage heart failure patients. Research aims to identify factors enhancing long-term survival and optimizing donor organ use in heart transplants.

Area of Science:

  • Cardiovascular Surgery
  • Transplantation Medicine
  • Immunology

Background:

  • Orthotopic heart transplantation (OHT) is the primary treatment for end-stage heart failure.
  • Global OHT volume is around 5000 procedures annually.
  • Survival rates post-transplantation have improved, with a current median of 12.2 years.

Purpose of the Study:

  • To identify factors influencing long-term survival after OHT.
  • To explore strategies for optimizing donor organ utilization.
  • To address limitations in OHT outcomes, including acute rejection and cardiac allograft vasculopathy (CAV).

Main Methods:

  • Analysis of existing OHT patient data and outcomes.
  • Review of International Society of Heart and Lung Transplantation (ISHLT) registry data.
  • Investigating donor and recipient characteristics impacting graft survival.

Main Results:

  • Despite advancements, long-term survival remains suboptimal.
  • Acute rejection and cardiac allograft vasculopathy (CAV) are significant challenges.
  • Donor organ shortage necessitates improved organ utilization strategies.

Conclusions:

  • Further research is crucial for enhancing long-term OHT outcomes.
  • Identifying predictive factors for survival and organ utility is a priority.
  • Optimizing organ utilization can improve the impact of heart transplantation.

Keywords:
Allograft vasculopathyCardiac transplantationDonor organImmunological differenceMicrovasculopathyPosttransplant mortalityPremenopausal female donorReviewSex mismatchTransfusion historyUnited Network for Organ Sharing

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