Related Experiment Video
Updated: Feb 5, 2026
05:39
Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
2.3K
Interplay between Body Size Measures and Thyroid Cancer Aggressiveness: A Retrospective Analysis
Thaís Gomes de Melo1, Ligia Vera Montali da Assumpção1, Denise Engelbrecht Zantut-Wittmann1
1Division of Endocrinology, Department of Internal Medicine, University of Campinas, Campinas, Brazil.
International Journal of Endocrinology
|September 19, 2018
Summary
Higher body weight and body surface area (BSA) are linked to increased extrathyroidal invasion in younger differentiated thyroid cancer (DTC) patients. Aggressive DTC cases showed significant weight loss, warranting further investigation.
Area of Science:
- Endocrinology
- Oncology
- Medical Research
Background:
- The relationship between body size and differentiated thyroid cancer (DTC) prognosis remains controversial.
- Understanding these associations is crucial for refining patient risk stratification and treatment strategies.
Purpose of the Study:
- To investigate the influence of body weight, body mass index (BMI), and body surface area (BSA) on the prognosis and evolution of differentiated thyroid cancer (DTC).
Main Methods:
- Retrospective analysis of 337 DTC patients' records.
- Assessment of body size measures (weight, BMI, BSA), clinical factors, and disease progression over a mean follow-up of 9.5 years.
Main Results:
- Higher baseline body weight and BSA were associated with extrathyroidal invasion in patients younger than 45 years.
- Patients with poorly differentiated tumors or distant metastasis experienced greater weight loss during follow-up.
- No direct correlation was observed between general body size and overall DTC evolution.
Conclusions:
- Elevated weight and BSA may indicate a higher risk of extrathyroidal invasion in younger DTC patients.
- Significant weight loss in specific aggressive DTC subgroups suggests a potential marker for disease activity.
- Further research into the mechanisms underlying weight changes and tumor aggressiveness is recommended.
Related Concept Videos
01:47Aggression
30.4K
Humans engage in aggression when they seek to cause harm or pain to another person. Aggression takes two forms depending on one’s motives: hostile or instrumental. Hostile aggression is motivated by feelings of anger with intent to cause pain; a fight in a bar with a stranger is an example of hostile aggression. In contrast, instrumental aggression is motivated by achieving a goal and does not necessarily involve intent to cause pain (Berkowitz, 1993); a contract killer who murders for...
30.4K
01:13Equipments Used to Measure Body Temperature
1.8K
Body temperature can be assessed using various devices and measured in Celsius or Fahrenheit.
Glass-bulb Thermometer:
Glass-bulb thermometers are hollow glass tubes with a bulb tip containing liquid such as ethanol or mercury. Historically, glass bulb mercury thermometers were the standard device to measure body temperature. Today, mercury thermometers are prohibited in many countries due to the hazardous effects of mercury and the risk of exposure if the glass bulb breaks. In general,...
Glass-bulb Thermometer:
Glass-bulb thermometers are hollow glass tubes with a bulb tip containing liquid such as ethanol or mercury. Historically, glass bulb mercury thermometers were the standard device to measure body temperature. Today, mercury thermometers are prohibited in many countries due to the hazardous effects of mercury and the risk of exposure if the glass bulb breaks. In general,...
1.8K
01:23The Thyroid Gland
7.7K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
7.7K
01:21Cancer Survival Analysis
768
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
768
01:18Functions of Thyroid Hormones
5.6K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
5.6K
01:21Secondary Motives: Affiliation Motivation and Aggression Motivation
705
Affiliation motivation is the intrinsic desire to connect with others and belong to a social group, which plays a crucial role in forming and maintaining personal relationships. This type of motivation is essential for psychological well-being, as it provides individuals with a sense of community and support. An example of this is a student who joins a study group in order to feel a sense of connection. People with high affiliation motivation actively seek social approval, take satisfaction in...
705