Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aging01:26

Aging

709
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
709
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

3.6K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.6K
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

3.6K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
3.6K
Bone Structure01:55

Bone Structure

51.8K
Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
51.8K
Bone Remodeling01:40

Bone Remodeling

40.5K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.5K
Compact Bone01:27

Compact Bone

16.6K
Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
16.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Retrospective Observation of Treatment Outcomes Using Decitabine-Combined Standard Conditioning Regimens Before Transplantation in Patients With Relapsed or Refractory Acute Myeloid Leukemia.

Frontiers in oncology·2021
Same author

Effect of chlorogenic acid on the quorum-sensing system of clinically isolated multidrug-resistant Pseudomonas aeruginosa.

Journal of applied microbiology·2021
Same author

Recent development of near-infrared photoacoustic probes based on small-molecule organic dye.

RSC chemical biology·2021
Same author

Effect of multidimensional comprehensive intervention on medication compliance, social function and incidence of MACE in patients undergoing PCI.

American journal of translational research·2021
Same author

Current status and influencing factors of fatigue in patients with rheumatoid arthritis: A cross-sectional study in China.

International journal of nursing practice·2021
Same author

Acquisition of Tigecycline Resistance by Carbapenem-Resistant <i>Klebsiella pneumoniae</i> Confers Collateral Hypersensitivity to Aminoglycosides.

Frontiers in microbiology·2021
Same journal

Mammalian Respiratory Chain Complex Assemblies and Their Links to Mitochondria Stress-Induced Human Diseases.

Advances in experimental medicine and biology·2026
Same journal

Enzyme Assemblies in Nucleotide Metabolism: Structure, Regulation, and Disease Implications.

Advances in experimental medicine and biology·2026
Same journal

The Pyruvate Dehydrogenase Complex: A 90-Year-Old Enigma Shaping the Future of Structural Enzymology.

Advances in experimental medicine and biology·2026
Same journal

Regulation of the Anti-termination RNA Transcription Complex by Lon-Mediated Lambda N Degradation.

Advances in experimental medicine and biology·2026
Same journal

PCNA Macromolecular Complexes: PCNA Serves as a Molecular Hub Regulating Multiple Cellular Processes Inside and Outside of the Nucleus.

Advances in experimental medicine and biology·2026
Same journal

Dynamic Assemblies in Genome Maintenance.

Advances in experimental medicine and biology·2026
See all related articles

Related Experiment Video

Updated: Feb 5, 2026

Models of Bone Metastasis
08:49

Models of Bone Metastasis

Published on: September 4, 2012

43.2K

Aging of the Bone.

Yu Wei1, Yao Sun2

  • 1Department of Implantology, School of Stomatology, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Tongji University, Shanghai, China.

Advances in Experimental Medicine and Biology
|September 21, 2018
PubMed
Summary
This summary is machine-generated.

Bone aging leads to net bone loss by disrupting the balance between bone formation and resorption. Understanding changes in bone cells like osteoblasts and osteoclasts is crucial for addressing osteoporosis.

Keywords:
BoneOsteoblastsOsteoclastsOsteocytesOsteoporosis

More Related Videos

Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast
10:41

Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast

Published on: August 20, 2013

13.3K
Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging
09:10

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging

Published on: January 30, 2026

71

Related Experiment Videos

Last Updated: Feb 5, 2026

Models of Bone Metastasis
08:49

Models of Bone Metastasis

Published on: September 4, 2012

43.2K
Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast
10:41

Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast

Published on: August 20, 2013

13.3K
Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging
09:10

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging

Published on: January 30, 2026

71

Area of Science:

  • Bone Biology
  • Aging Research
  • Skeletal Physiology

Background:

  • Bone provides structural support, houses marrow, and regulates calcium homeostasis.
  • Aging disrupts the balance between bone resorption and formation, leading to net bone loss.
  • Osteoporosis is a significant health concern in aging populations.

Purpose of the Study:

  • To investigate the age-related changes in bone tissue.
  • To examine alterations in bone cells, including osteoblasts, osteoclasts, and osteocytes, during aging.
  • To understand the cellular mechanisms underlying age-related bone loss and osteoporosis.

Main Methods:

  • Review of existing literature on bone aging.
  • Analysis of cellular functions of osteoblasts, osteoclasts, and osteocytes in aging bone.
  • Focus on the balance between bone formation and resorption processes.

Main Results:

  • Aging is characterized by decreased bone formation and increased bone resorption.
  • Specific changes occur in osteoblasts, osteoclasts, and osteocytes that contribute to bone loss.
  • The delicate balance regulating calcium homeostasis is compromised during bone aging.

Conclusions:

  • Age-related bone loss is a complex process involving cellular dysfunction.
  • Understanding these cellular changes is key to developing strategies for preventing and treating osteoporosis.
  • Further research into bone aging mechanisms can inform therapeutic interventions.