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Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging
Published on: January 30, 2026
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Biomarkers of Aging
1Department of Gerontology and Geriatrics, Shengjing Hospital of China Medical University, Shenyang, China. xiaojuan.bai@163.com.
Advances in Experimental Medicine and Biology
|September 21, 2018
Summary
Biological age, assessed using multiple biomarkers, offers a more accurate measure of aging than chronological age. This biological age score (BAS) reveals aging rates stabilize after 75 years.
Area of Science:
- Gerontology and Biomarker Research
- Molecular and Cellular Biology
- Biostatistics and Bioinformatics
Background:
- Biomarkers of aging predict functional status and health outcomes more accurately than chronological age alone.
- Current aging biomarkers (genes, proteins) are insufficient to capture the complexity of the aging process.
- A composite measure, biological age, better reflects an individual's true aging status.
Purpose of the Study:
- To develop a comprehensive biological age score (BAS) using multiple aging biomarkers.
- To evaluate the aging trajectory and identify critical age thresholds.
- To provide a quantitative standard for individualized aging assessment.
Main Methods:
- Selected 7 key aging biomarkers from 108 variables based on factor score analysis.
- Established the biological age score (BAS) formula: BAS = 0.248(CA) + 0.195(IMT) - 0.196(EDV) - 0.167(E/A) - 0.166(MVEL) + 0.188(PP) + 0.182(FIB) + 0.193(CYSC).
- Analyzed the aging rate in relation to chronological age.
Main Results:
- The developed biological age score (BAS) integrates multiple aging indicators.
- Aging rate increased progressively before 75 years of age.
- After 75 years, the rate of aging entered a stable plateau.
Conclusions:
- Biological age, derived from a composite of biomarkers, is a superior indicator of aging than chronological age.
- The established BAS provides a quantitative measure for individualized aging.
- Future research may require novel approaches to fully understand and evaluate aging mechanisms.
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