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ACR-ACNM Practice Parameter for the Performance of Fluorine-18 Fluciclovine-PET/CT for Recurrent Prostate Cancer
Bital Savir-Baruch1, Kevin P Banks, Jonathan E McConathy
1From the UT Southwestern Medical Center Dallas, TX.
Clinical Nuclear Medicine
|October 17, 2018
Summary
Fluciclovine positron-emission tomography (PET)/computed tomography (CT) aids in detecting prostate cancer recurrence after initial therapy. This advanced imaging helps differentiate local from extraprostatic recurrence, guiding patient management.
Area of Science:
- Oncology
- Nuclear Medicine
- Radiology
Background:
- Prostate cancer recurrence, indicated by elevated prostate-specific antigen (PSA), affects up to 50% of patients post-therapy.
- Distinguishing local from extraprostatic recurrence is crucial for effective patient management.
- Upregulated amino acid transport in prostate cancer cells presents a target for functional imaging.
Purpose of the Study:
- To provide a clinical practice document for fluciclovine PET/CT in evaluating suspected prostate cancer recurrence.
- To outline the performance standards for fluciclovine PET/CT in biochemical recurrence settings.
Main Methods:
- Development of a clinical practice document through collaboration between the American College of Radiology (ACR) and American College of Nuclear Medicine (ACNM).
- Focus on fluciclovine (anti-1-amino-3-F-18-fluorocyclobutane-1-carboxylic acid, FACBC) as an artificial amino acid PET tracer.
- Evaluation of patients with suspected prostate cancer recurrence based on elevated PSA levels.
Main Results:
- Fluciclovine PET/CT demonstrates utility in diagnosing recurrent prostate cancer.
- This imaging modality offers significant added value compared to conventional imaging techniques.
- Functional imaging targeting cancer metabolism aids in differentiating recurrence patterns.
Conclusions:
- Fluciclovine PET/CT is a valuable tool for evaluating prostate cancer recurrence.
- The practice document provides guidance for the appropriate performance of this diagnostic procedure.
- Accurate localization of recurrent prostate cancer improves treatment strategies.
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