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Modification of Titanium Implant and Titanium Dioxide for Bone Tissue Engineering.
Tae-Keun Ahn1, Dong Hyeon Lee2, Tae-Sup Kim1
1Department of Orthopaedic Surgery, CHA Bundang Medical Center, CHA University School of Medicine, Gyeonggi-do, South Korea.
Advances in Experimental Medicine and Biology
|October 26, 2018
Summary
Titanium implants are enhanced with titanium dioxide (TiO2) coatings for better bone integration in tissue engineering. Research explores TiO2 nanotubes and scaffolds to improve implant performance and bone regeneration.
Area of Science:
- Biomaterials Science
- Orthopedic Engineering
- Tissue Engineering
Background:
- Titanium (Ti) implants are widely used in dental and orthopedic applications due to their excellent properties.
- Achieving robust osteointegration between Ti implants and bone necessitates surface modifications.
- Titanium dioxide (TiO2) modifications, including nanotubes and porous scaffolds, show promise for enhancing bone regeneration.
Purpose of the Study:
- To review the properties of Ti and Ti-based implants with modifications for bone tissue engineering.
- To discuss the progress and potential of TiO2 nanotubes and scaffolds in improving osteointegration and bone defect repair.
Main Methods:
- Review of existing literature on Ti implant modifications for bone tissue engineering.
- Analysis of TiO2 nanotubes and porous scaffolds as coating materials and scaffolding materials.
- Exploration of strategies to optimize TiO2 scaffolds, including combination with drugs, cells, and other biomaterials.
Main Results:
- Plasma-sprayed hydroxyapatite (HA) is a common modification for Ti implants.
- TiO2 nanotubes demonstrate potential for improving osteogenic activity around implants.
- Porous TiO2 scaffolds exhibit high biocompatibility and osteoconductivity for bone defects, though load-bearing applications are limited.
Conclusions:
- Surface modification of Ti implants is crucial for successful osteointegration.
- TiO2-based materials, particularly nanotubes and scaffolds, offer significant potential in bone tissue engineering.
- Further optimization of TiO2 scaffolds is needed for broader clinical applications, especially in load-bearing situations.
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