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ASSESSMENT OF DIRECT RESULTS OF CERVICAL CANCER COMBINED TREATMENT.

Yu Fomenko1, A Cialkowska-Rysz1, L Muravlyova1

  • 1Karaganda State Medical University, Kazakhstan; Medical University of Lodz, Poland.

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This study found that combining radiotherapy with cisplatin significantly improved cervical cancer treatment outcomes compared to radiotherapy alone or with ftorafur. Cisplatin combination therapy showed higher complete response rates and tumor regression.

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Area of Science:

  • Oncology
  • Radiotherapy
  • Chemotherapy

Background:

  • Cervical cancer remains a significant global health challenge.
  • Optimizing treatment strategies for cervical cancer is crucial for improving patient outcomes.

Purpose of the Study:

  • To evaluate the immediate results of combined treatment for cervical cancer.
  • To compare the efficacy of radiotherapy (RT) with ftorafur versus RT with cisplatin.

Main Methods:

  • A study involving 177 cervical cancer patients across stages IIA, IIB, and III.
  • Patients were divided into three groups: control (RT only), investigative group 1 (RT + ftorafur), and investigative group 2 (RT + cisplatin).
  • Treatment effectiveness was assessed using WHO criteria (1978), with a focus on complete and clinical response rates and tumor regression.

Main Results:

  • Radiotherapy combined with cisplatin demonstrated a 28.3% increase in complete and clinical responses compared to RT alone.
  • Cisplatin combination therapy showed a statistically significant increase in cervical cancer regression by 26.7% versus RT alone and 24.1% versus ftorafur combination.
  • Hematological toxicity was most pronounced with cisplatin but did not necessitate treatment interruption; RT alone had the lowest toxicity.

Conclusions:

  • Combined radiotherapy and cisplatin is an effective treatment for cervical cancer, yielding higher response and regression rates.
  • While cisplatin combination therapy presents higher hematological toxicity, it is manageable and does not impede treatment.
  • Further research into optimizing cisplatin dosage and managing toxicity in cervical cancer treatment is warranted.