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Updated: Feb 2, 2026
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Isolation and Characterization of Human Umbilical Cord-derived Mesenchymal Stem Cells from Preterm and Term Infants
Published on: January 26, 2019
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Characterization of chylomicron in preterm infants
Ayako Seimiya1, Tomoo Okada1,2, Nobuhiko Nagano1
1Department of Pediatrics and Child Health, Nihon University School of Medicine, Itabashi, Tokyo, Japan.
Summary
Preterm infants show altered chylomicron composition with higher cholesterol and lower triglycerides compared to term infants. This less-lipidated profile persists postnatally, suggesting ongoing influences on infant lipid metabolism.
Area of Science:
- Neonatal physiology
- Lipid metabolism in infants
- Perinatal nutrition
Background:
- Investigating lipid profiles in preterm infants is crucial for understanding their unique physiological adaptations.
- Chylomicrons play a key role in transporting dietary fats, and their composition can indicate metabolic health.
Purpose of the Study:
- To analyze cholesterol and triglyceride levels within the chylomicron fraction of preterm infants.
- To compare these levels at birth and during the early postnatal period with those of term infants.
Main Methods:
- Studied 133 infants (59 preterm, 74 term).
- Measured chylomicron cholesterol and triglyceride concentrations using high-performance liquid chromatography.
- Analyzed data from cord blood and 1-month postnatal samples.
Main Results:
- Preterm infants exhibited higher chylomicron cholesterol and lower triglycerides than term infants.
- The triglyceride/cholesterol ratio in chylomicrons was significantly lower in preterm infants.
- This ratio positively correlated with gestational age at birth and at 1 month.
Conclusions:
- Preterm infants possess a less-lipidated chylomicron composition at birth and 1 month post-birth.
- Prenatal factors likely influence chylomicron lipidation, with effects extending into the early postnatal period.
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