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Updated: Feb 2, 2026

Analysis of Oxidative Stress in Zebrafish Embryos
Published on: July 7, 2014
Effects of Limb Revascularization Procedures on Oxidative Stress
Ahmed Ismaeel1, Ramon Lavado2, Robert S Smith3
1Department of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, Florida.
Abstract:
Revascularization procedures to treat patients with peripheral artery disease are among the most common operations performed by vascular surgeons. However, there are major limitations to revascularizations, readmission rates due to procedural complications are high, and greater risks of cardiovascular and limb adverse outcomes have been reported for patients with peripheral artery disease undergoing limb revascularization. Specifically, surgical revascularization may be associated with increased generation of reactive oxygen species based on the ischemia reperfusion injury theory, as restored blood flow and reoxygenation of ischemic areas may be accompanied by increased oxidative stress. In this review, we present the current evidence regarding the effects of revascularization procedures on oxidative stress. We also discuss potential therapeutic interventions to prevent ischemia reperfusion injury-mediated tissue damage.
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