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Updated: Feb 2, 2026

A Protocol for Explant Cultures of IDH1-mutant Diffuse Low-grade Gliomas
Published on: May 9, 2025
Mapping in Low-Grade Glioma Surgery: Low- and High-Frequency Stimulation
Marco Rossi1, Sepehr Sani2, Marco Conti Nibali1
1Unit of Neurosurgical Oncology, Department of Hematology and Hemato-Oncology Università degli Studi di Milano, Via Manzoni 56, 20089 Rozzano (MI), Italy; Neurosurgical Oncology, Humanitas Research Hospital, IRCCS, Via Manzoni 56, 20089 Rozzano (MI), Italy.
Abstract:
Surgery for lower grade glioma requires the use of brain mapping techniques to identify functional boundaries, which represent the limit of the resection. Two stimulation paradigms are currently available and their use should be tailored to the clinical context to extend tumor removal and decrease the odds of postoperative permanent deficits.
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