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Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation
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Is This Organ Donor Safe?: Donor-Derived Infections in Solid Organ Transplantation

Staci A Fischer1

  • 1The Warren Alpert Medical School of Brown University, 222 Richmond Street, Providence, RI 02903, USA; Accreditation Council for Graduate Medical Education, 401 North Michigan Avenue, Suite 2000, Chicago, IL 60611, USA.

The Surgical Clinics of North America
|November 26, 2018
PubMed

Insights

Organ donor infections can cause severe illness or death in transplant recipients. Careful screening of organ donors for infections, especially meningoencephalitis, is crucial to improve transplant safety and outcomes.

Area of Science:

  • Transplantation immunology
  • Infectious disease transmission
  • Public health

Background:

  • Infection is a common and serious complication following solid organ transplantation.
  • Undiagnosed infections in organ donors can lead to severe morbidity and mortality in recipients.
  • Recent outbreaks highlight the risks associated with using donors with potential central nervous system infections.

Purpose of the Study:

  • To emphasize the critical need for vigilance regarding donor-derived infections in organ transplantation.
  • To advocate for stringent screening protocols for organ donors to prevent transmission of infectious agents.
  • To improve patient outcomes and reduce mortality associated with solid organ transplantation.

Main Methods:

  • Review of recent outbreaks of deceased donor-derived infections.
  • Analysis of the impact of unrecognized infections on immunosuppressed transplant recipients.
  • Evaluation of current screening practices for organ donors.

Main Results:

  • Deceased donor-derived infections have led to significant mortality and morbidity.
  • Donors with possible meningoencephalitis pose a substantial risk for transmission.
  • Effective screening is essential for mitigating infection transmission risks.

Conclusions:

  • Vigilance and caution are necessary when considering donors with potential meningoencephalitis.
  • Comprehensive screening of organ donors for transmissible infections is paramount.
  • Implementing robust screening measures will enhance the safety and success of organ transplantation.
Keywords:
Donor-derived infectionsDonor-transmitted infectionsLymphocytic choriomeningitis virusOrgan donor screeningTransplant infections

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