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Coordination-assembled supramolecular nanoplatforms: structural modulation and theranostic applications
Han Zhang1, Lei Kang2, Qianli Zou3
1State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, China; Key Lab for Colloid and Interface Chemistry of Education Ministry, School of Chemistry and Chemical Engineering, Shandong University, Jinan, 250100, China.
Current Opinion in Biotechnology
|December 1, 2018
Summary
Coordination-assembled supramolecular nanoplatforms offer a versatile approach for advanced theranostics. These systems show great potential for disease treatment by enabling property modulation for improved clinical applications.
Area of Science:
- Nanotechnology
- Materials Science
- Chemical Biology
Background:
- Theranostics, combining therapy and diagnostics, are crucial for treating diseases.
- Coordination-assembled supramolecular nanoplatforms are emerging as advanced theranostic candidates.
- These platforms offer advantages in fabrication, robustness, and versatility over existing systems.
Purpose of the Study:
- To highlight recent advances in coordination-assembled supramolecular nanoplatforms.
- To explore the modulation of structures and properties for theranostic applications.
- To discuss the potential of these nanoplatforms in clinical settings.
Main Methods:
- Coordination-based supramolecular self-assembly for nanoplatform fabrication.
- Modulation of physicochemical properties through structural design.
- Exploration of theranostic applications in disease treatment.
Main Results:
- Demonstration of facile, robust, and versatile fabrication of nanoplatforms.
- Successful modulation of nanoplatform properties via self-assembly.
- Identification of promising theranostic applications for various diseases.
Conclusions:
- Coordination-assembled supramolecular nanoplatforms represent a significant advancement in theranostics.
- These platforms offer tunable properties for enhanced therapeutic and diagnostic efficacy.
- The long-term goal is the development of high-performance theranostics for clinical use.
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