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Related Concept Videos

Encoding01:19

Encoding

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Information enters the brain through encoding, which is the input of information into the memory system. Once sensory information is received from the environment, the brain labels or codes it. The information is then organized with similar information and connected to existing concepts. Encoding occurs through automatic processing and effortful processing.
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A chemical reaction is a process by which the bonds in the atoms of substances are rearranged to generate new substances. Matter cannot be created or destroyed in a chemical reaction—the same type and number of atoms that make up the reactants are still present in the products. Merely, the rearrangement of chemical bonds produces new compounds.
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As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
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The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
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Retroviruses and retrotransposons both insert copies of their genetic elements into the genome of the host cell. Thus, the viral genes are passed on when the host genome is replicated or translated. A typical retroviral DNA sequence contains 3-4 genes that encode the different proteins required for its structural assembly and function as a molecular parasite. This DNA is transcribed into a single mRNA, which is very similar in structure to conventional mRNAs, i.e., it is capped at the 5’...
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LTR retrotransposons are class I transposable elements with long terminal repeats flanking an internal coding region. These elements are less abundant in mammals compared to other class I transposable elements. About 8 percent of human genomic DNA comprises LTR retrotransposons. Some of the common examples of LTR retrotransposons are Ty elements in yeast and Copia elements in Drosophila.
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Identification and Protection of the Recurrent Laryngeal Nerve during Transoral Robotic Thyroidectomy
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Bidirectional Recurrent Auto-Encoder for Photoplethysmogram Denoising.

Joonnyong Lee, Sukkyu Sun, Seung Man Yang

    IEEE Journal of Biomedical and Health Informatics
    |December 12, 2018
    PubMed
    Summary
    This summary is machine-generated.

    This study introduces a new algorithm, the bidirectional recurrent denoising auto-encoder (BRDAE), to effectively remove noise from photoplethysmography (PPG) signals. The BRDAE enhances signal quality and improves heart rate detection accuracy in real-world conditions.

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    Area of Science:

    • Biomedical Engineering
    • Signal Processing
    • Wearable Technology

    Background:

    • Photoplethysmography (PPG) is widely used in wearables but susceptible to noise in uncontrolled environments.
    • Existing PPG denoising methods often require controlled settings or complex multi-step processes.
    • Effective noise reduction is crucial for reliable PPG signal interpretation.

    Purpose of the Study:

    • To develop a novel, robust algorithm for denoising PPG signals.
    • To enhance PPG signal quality beyond simple noise removal, focusing on waveform feature accentuation.
    • To validate the algorithm's performance on diverse real-world PPG datasets.

    Main Methods:

    • A bidirectional recurrent denoising auto-encoder (BRDAE) was developed for PPG signal denoising.
    • The BRDAE model was trained and validated using artificially augmented noisy PPG data.
    • The algorithm was tested on large open databases including intensive care unit (ICU) patient data and ambulatory data.

    Main Results:

    • The BRDAE achieved a 7.9 dB improvement in signal-to-noise ratio (SNR) during validation.
    • Denoised PPG signals demonstrated statistically significant improvements in heart rate detection accuracy.
    • The method showed enhanced correlation to reference and reduced root-mean-squared error compared to original PPG signals.

    Conclusions:

    • The proposed BRDAE algorithm is an effective solution for denoising PPG signals.
    • The method offers benefits beyond traditional denoising, including PPG feature accentuation.
    • This approach holds promise for improving pulse waveform analysis in mobile healthcare applications.