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Updated: Jan 31, 2026

Myocardial Infarction and Functional Outcome Assessment in Pigs
Published on: April 25, 2014
EFFECT OF OBESITY PRESENCE ON INSULIN-LIKE GROWTH FACTOR-1 AND ENDOSTATIN IN PATIENTS WITH MYOCARDIAL INFARCTION
D Martovytskyi1, P Kravchun1, O Shelest1
1Kharkiv National Medical University, Ukraine.
Abstract:
Aim of the study - to study the markers of angiogenesis‒IGF-1 and endostatin ‒ in patients with acute myocardial infarction according to the presence or absence of obesity. The study involved 105 patients with acute myocardial infarction (MI) with concomitant obesity who were treated in the infarctional department (mean age 64.6±7.4 years), 55 of them ‒ with acute MI with comorbidant obesity and 60 patients ‒ with acute MI without obesity. The groups were comparable by sex and age. The control group consisted of 20 healthy persons of corresponding age and sex. In obese and non-obese patients with MI the levels of IGF-1 were statistically significantly higher than those of persons in the control group (p<0.05). The levels of IGF-1 in acute MI with obesity were statistically significantly higher than in the serum of patients with MI without obesity (180.64±12.2 ng/ml and 128.76±8.1 ng/ml, accordingly, p<0.05). Patients with acute MI showed increased IGF-1 and endostatin in comparison with the controls. The presence of obesity in MI was accompanied by an increased IGF-1 and decreased endostatin as compared to patients with MI. In patients with MI and obesity, high activity of IGF-1 was accompanied by high levels of proaterogenic lipids with reduced volumes and thickening of the interventricular wall of the left ventricle. Unlike IGF-1 hyperendostatinemia was associated with left ventricle dilation.
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