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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Recording Horizontal Saccade Performances Accurately in Neurological Patients Using Electro-oculogram
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[Neurology].

Elissavet Eskioglou1, David Benninger1, Gabriella Di Virgilio1

  • 1Service de neurologie, Département des neurosciences cliniques, CHUV, 1011 Lausanne.

Revue Medicale Suisse
|January 11, 2019
PubMed
Summary
This summary is machine-generated.

New therapeutic strategies show promise for neurological disorders. These include advanced treatments for stroke, migraine, multiple sclerosis, epilepsy, Alzheimer's disease, Parkinson's disease, and myasthenia gravis, improving patient outcomes.

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Area of Science:

  • Neurology
  • Neuroscience
  • Medical Imaging

Background:

  • Advancements in medical imaging facilitate timely interventions for conditions like stroke.
  • Emerging therapies offer new hope for managing chronic neurological diseases.
  • Understanding disease mechanisms is crucial for developing targeted treatments.

Purpose of the Study:

  • To review recent developments in the treatment of various neurological conditions.
  • To highlight the efficacy of novel therapeutic approaches.
  • To provide an overview of current best practices and future directions in neurology.

Main Methods:

  • Literature review of recent studies on neurological treatments.
  • Analysis of clinical trial data for novel therapies.
  • Synthesis of information on diagnostic criteria and treatment efficacy.

Main Results:

  • Thrombolysis and late thrombectomy are viable for stroke with appropriate imaging.
  • Anti-CGRP monoclonal antibodies demonstrate high efficacy in migraine treatment.
  • Siponimod significantly reduces disability progression in secondary progressive multiple sclerosis (MS).
  • Switching to generic levetiracetam does not trigger epileptic seizures.
  • Biomarker-based definitions of Alzheimer's disease enhance mechanistic understanding.
  • Levodopa-carbidopa intestinal gel and apomorphine infusion reduce motor fluctuations in Parkinson's disease.
  • Eculizumab serves as an alternative for severe myasthenia gravis.

Conclusions:

  • Recent therapeutic advancements offer improved management options for diverse neurological disorders.
  • Personalized medicine approaches, guided by biomarkers and imaging, are transforming neurological care.
  • The reviewed treatments represent significant progress in addressing unmet needs in neurology.