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Therapeutic evaluation of omeprazole
M H Adams1, J D Ostrosky, C F Kirkwood
1Department of Pharmacy and Pharmaceutics, Medical College of Virginia-Virginia Commonwealth University, Richmond.
Clinical Pharmacy
|October 1, 1988
Summary
Omeprazole, a proton pump inhibitor, effectively reduces gastric acid secretion and treats ulcers and acid-related disorders. It offers superior efficacy compared to H2-receptor antagonists for duodenal ulcers and reflux esophagitis.
Area of Science:
- Pharmacology
- Gastroenterology
Background:
- Omeprazole is a substituted benzimidazole.
- It uniquely inhibits the proton pump (H+,K+-ATPase), blocking gastric acid secretion.
Purpose of the Study:
- To review the pharmacology, pharmacokinetics, clinical efficacy, adverse effects, and administration of omeprazole.
Main Methods:
- Review of existing literature on omeprazole.
Main Results:
- Omeprazole inhibits basal and stimulated gastric acid secretion, reducing acidity and volume.
- It demonstrates superior efficacy over H2-receptor antagonists for duodenal ulcers and reflux esophagitis.
- Common side effects include gastrointestinal complaints; elevated liver enzymes are a noted laboratory abnormality.
Conclusions:
- Omeprazole is a valuable agent for managing gastrointestinal ulcers and hypersecretory conditions.
- Its unique mechanism provides significant therapeutic benefits in acid-related disorders.