Related Experiment Video
Updated: Jan 30, 2026

A Protocol for Analyzing Hepatitis C Virus Replication
Published on: June 26, 2014
[A CASE OF IMPORT OF GENOTYPE 4 HEPATITIS E VIRUS INTO RUSSIA]
Aim:
Description of the first documented case of imported hepatitis E, associated with geno- type 4 of HEV and introduced from southern France.
Materials And Methods:
Clinical, epidemio- logic and laboratory analysis of the imported case of disease of hepatitis E was carried out. Phylogenetic analysis of nucleotide sequences of HEV isolate, taken from the patient, was carried out.
Results:
Epidemiologic analysis allowed to assume imported character of the detected case of HEV-infection. Comparative analysis ofnucleotide sequences of regions ofthe open reading frame 2 (300 nt) and open reading frame 1 (721 nt) of HEV genome, isolated from the patient, showed identity of this isolate with variants of genotype 4 HEV, isolated in France in 2009 - 2011 from patients with autochthonous hepatitis E.
Conclusion:
The results obtained confirm the case of import into Russia of genotype 4 HEV from south-eastern France (Corsica), where spread of this virus genotype is observed in recent years.
Related Concept Videos
Protein Import into the Peroxisomes
Peroxisomal Protein Import:
Peroxisomes lack the genetic machinery required to code for their own proteins. Hence, most peroxisomal membrane, lumenal and transmembrane proteins are synthesized in the cytoplasm or ER and transported to the peroxisome...
ABC Transporters: Importer
In bacteria, based on the number of transmembrane helices and the chemical nature of their substrates, the ABC importers can be divided into three types:
Nuclear Localization Signals and Import
What are Viruses?
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment
Hepatic Portal System
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is...

