STUDY OF BONE TISSUE REPARATION AFTER A FEMUR FRACTURE DEPENDING ON THE CORRECTION OF ARTERIAL HYPERTENSION IN MODEL...

Area of Science:

• Biomedical Engineering
• Orthopedics
• Cardiology

Background:

• Bone remodeling and blood pressure regulation share common genetic factors, leading to comorbid diseases like osteoporosis and hypertension.
• Proximal femur fractures are a significant complication of osteoporosis, posing serious medical and social challenges.
• Simultaneous treatment of syntropic diseases can maximize positive health outcomes.

Purpose of the Study:

• To evaluate bone tissue repair after proximal femur fractures and intramedullary osteosynthesis in the context of arterial hypertension.
• To assess the impact of enalapril monotherapy on blood pressure and bone healing in hypertensive rats post-surgery.

Main Methods:

• Utilized a rat model (Wistar and SHR lines) to study proximal femur fractures and intramedullary osteosynthesis.
• Administered enalapril monotherapy to a group of genetically hypertensive rats during the postoperative period.
• Monitored blood pressure dynamics and assessed fracture zone adhesion in both treated and untreated hypertensive groups.

Main Results:

• Enalapril treatment normalized systolic blood pressure in hypertensive rats within three weeks, comparable to normotensive controls.
• Fracture site adhesion indicators were significantly higher in the enalapril-treated group compared to the uncorrected hypertensive group.
• Adequate blood pressure correction positively influenced bone reparative capabilities.

Conclusions:

• Postoperative blood pressure management favorably impacts bone healing and enhances the success of surgical interventions for fractures.
• Targeting comorbid conditions like hypertension alongside orthopedic treatment can improve patient outcomes.