STUDY OF BONE TISSUE REPARATION AFTER A FEMUR FRACTURE DEPENDING ON THE CORRECTION OF ARTERIAL HYPERTENSION IN MODEL...

The processes of bone remodeling and regulation of blood pressure are caused by common genetic determinants underlying the development of these diseases. To solve practical medical problems, it seems relevant to carry out the correction and treatment of syntropic diseases at the same time with the aim of achieving the maximum positive effect. The most serious complication of osteoporosis is bone fractures, especially fractures of the proximal femur, which are a serious medical and social problem. The aim of our work was to evaluate the repair of bone tissue after fractures of the proximal femur with subsequent intramedullary osteosynthesis on the background of arterial hypertension and its correction. A model object was used in the work - gray rats, lines Wistar and SHR, which were operated on. For the animals of one of the groups with genetically determined arterial hypertension, correction of the above-mentioned pathology in the form of enalapril monotherapy in the postoperative period was applied. In this group, the picture of the dynamics of blood pressure indices corresponded to the cumulative effect of enalapril - after three weeks of taking the drug, the rats' systolic blood pressure indices corresponded to those of normotensive animals, and the indicators of adhesion of the fracture zone were higher than in the group of rats with arterial hypertension, which was not corrected. Adequate correction of the level of blood pressure in the postoperative period favorably affects the reparative capabilities of the bone, while at the same time increasing the chances of positive results of surgical treatment of patients.