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Updated: Jan 26, 2026
07:44
In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
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Optical Coherence Tomography Angiography and Glaucoma: A Brief Review
Sasan Moghimi1, Huiyuan Hou, Harsha L Rao
1From the Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California, San Diego, CA, United States; and Narayana Nethralaya, Bangalore, India.
Summary
Optical coherence tomography angiography (OCTA) offers non-invasive assessment of retinal vasculature, aiding in glaucoma diagnosis and monitoring. OCTA shows good repeatability and can detect early glaucoma, providing valuable insights into disease progression.
Area of Science:
- Ophthalmology
- Medical Imaging
- Glaucoma Research
Background:
- Optical coherence tomography angiography (OCTA) is an emerging non-invasive ocular imaging technique.
- OCTA enables detailed assessment and measurement of retinal and optic nerve head vasculature.
Purpose of the Study:
- To evaluate the utility of OCTA in glaucoma assessment.
- To explore OCTA's role in quantitative vessel density measurement and disease monitoring.
Main Methods:
- Utilized OCTA for non-invasive imaging of ocular vascular structures.
- Performed quantitative assessment of vessel density in the retina and optic nerve head.
- Evaluated repeatability, reproducibility, and diagnostic capabilities of OCTA in glaucoma.
Main Results:
- OCTA demonstrated good repeatability and reproducibility.
- Vessel density measurements were influenced by subject, eye, and disease factors.
- OCTA successfully differentiated glaucoma from normal eyes and showed potential for early detection.
- OCTA exhibited a floor effect at advanced stages, but provided progression risk information.
Conclusions:
- OCTA is a valuable tool for glaucoma assessment, offering insights into vascular changes.
- Despite higher variability than OCT, OCTA shows promise for monitoring glaucoma progression.
- OCTA aids in early glaucoma detection and risk stratification for disease progression.
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