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Exploring the Critical Factors Limiting Polyaniline Biocompatibility
Věra Kašpárková1,2, Petr Humpolíček3,4, Jaroslav Stejskal5
1Centre of Polymer Systems, Tomas Bata University in Zlin, Tr. T. Bati 5678, 760 01 Zlin, Czech Republic. vkasparkova@utb.cz.
Polymers
|April 10, 2019
Summary
This study determined the cytotoxicity of polyaniline precursors and identified impurities affecting polyaniline
Area of Science:
- Biomedical engineering
- Materials science
Background:
- Polyaniline (PANI) is widely used in biomedicine.
- Data on PANI precursor cytotoxicity and impurities is limited.
Purpose of the Study:
- Assess cytotoxicity of aniline, aniline hydrochloride, and ammonium persulfate.
- Identify cell death mechanisms induced by precursors.
- Evaluate PANI cytotoxicity based on doping acid and impurities.
Main Methods:
- MTT assay for cytotoxicity.
- Flow cytometry for cell death analysis.
- High-performance liquid chromatography (HPLC) for impurity analysis.
Main Results:
- Ammonium persulfate showed higher cytotoxicity than aniline hydrochloride.
- Precursors exhibited synergistic cytotoxicity.
- Polyaniline doped with phosphoric acid had the lowest cytotoxicity.
- Residual ammonium persulfate and polar substances contributed to PANI cytotoxicity.
Conclusions:
- Cytotoxicity of polyaniline is linked to precursor residues and impurities.
- Purification methods are crucial for developing cytocompatible polyaniline for biomedical applications.
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