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Published on: February 7, 2018
A Versatile Biocompatible Antibiotic Delivery System Based on Self-Assembling Peptides with Antimicrobial and
Franziska Koch1,2,3, Katharina Ekat2,3,4, David Kilian1
1School of Life Sciences, Institute for Chemistry and Bioanalytics, University of Applied Sciences and Arts Northwestern Switzerland, 4132, Muttenz, Switzerland.
Self-assembling peptide (SAP) hydrogels show promise for treating periodontitis. These novel materials exhibit antimicrobial properties, support stem cell regeneration, and can deliver antibiotics effectively, offering a new therapeutic avenue.
Area of Science:
- Biomaterials Science
- Periodontal Medicine
- Regenerative Dentistry
Background:
- Periodontitis is a chronic inflammatory disease requiring new treatments due to complex oral microbiome.
- Self-assembling peptide (SAP) hydrogels offer potential for periodontal therapy due to their unique properties.
Purpose of the Study:
- To evaluate two SAP hydrogels (P11-4 and P11-28/29) for periodontal applications.
- To assess their antimicrobial activity, regenerative potential, and antibiotic delivery capabilities.
Main Methods:
- Tested SAP hydrogels against Porphyromonas gingivalis.
- Assessed human dental follicle stem cell (DFSC) viability and osteogenic differentiation on hydrogels.
- Incorporated antibiotics (tetracycline, ciprofloxacin, doxycycline) and evaluated release kinetics.
Main Results:
- P11-28/29 hydrogels showed significant antibacterial effects on P. gingivalis.
- P11-4 hydrogels maintained DFSC metabolic activity, indicating good viability and regenerative potential.
- Both hydrogels enhanced osteogenic differentiation of DFSCs and allowed controlled antibiotic release up to 120 hours.
Conclusions:
- P11-SAP hydrogels possess intrinsic antimicrobial activity and promote stem cell regeneration.
- These hydrogels are suitable for controlled antibiotic delivery, making them promising candidates for novel periodontal therapies.
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