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Updated: Jan 25, 2026
Author Spotlight: Enhancing Dental Pulp Research with Improved Mouse Models
Published on: October 27, 2023
Changes in the Periodontium and Pulp in ISIAH Rats Caused by Stress Exposures in Different Modes
L R Kolesnikova1,2, M A Darenskaya3, L I Kolesnikova1,4
1Research Center for Family Health and Human Reproduction Problems, Irkutsk, Russia.
Abstract:
It was shown that the intensity of morphological changes in the dental system tissues (periodontium and pulp) of ISIAH rats depends on the mode of stress exposure. Acute stress was associated with a significant increase in the area of periodontal and pulp vessels, a decrease in the area of connective tissue of these components, and an increase in the thickness of the vascular endothelium. Chronic stress in these animals induced an increase in the thickness of the endothelial layer of the periodontal and pulp vessels, fibromatosis (increase in the number of fibroblasts), and a sharp decrease in the level of odontoblasts.
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