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Updated: Jan 25, 2026
08:47
Culturing Mouse Cardiac Valves in the Miniature Tissue Culture System
Published on: October 19, 2015
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Role of Periostin in Cardiac Valve Development
Roger R Markwald1, Ricardo A Moreno-Rodriguez2, Sibnath Ghatak2
1Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina CRI 609, Charleston, SC, USA. markwald@musc.edu.
Advances in Experimental Medicine and Biology
|May 1, 2019
Summary
Periostin is crucial for heart valve development, promoting cell migration, survival, and collagen production. Its absence leads to improper valve remodeling and potential disease.
Area of Science:
- Cardiovascular Biology
- Developmental Biology
- Molecular Biology
Background:
- Periostin is implicated in adult cardiac remodeling.
- Its role in heart valve development is the focus of this review.
Purpose of the Study:
- To review periostin's function as a valvulogenic gene during heart valve development.
- To explore periostin's role in cellular behaviors and signaling pathways governing valve morphogenesis.
Main Methods:
- Review of existing literature on periostin's function in valvular development.
- Analysis of periostin null phenotypes to understand its specific contributions.
- Examination of downstream signaling pathways activated by periostin.
Main Results:
- Periostin is expressed in developing heart valve cushion tissues.
- Periostin promotes cell migration, survival, collagen secretion, and differentiation.
- Signaling involves integrin receptors, Akt/PI3K, Erk/MapK, and Pak1 pathways.
- Periostin is essential for proper valve remodeling and maturation.
Conclusions:
- Periostin is a key valvulogenic gene essential for heart valve development and maturation.
- Dysregulation of periostin-mediated remodeling can lead to degenerative valve diseases.
- Periostin influences mesenchymal cell fate and lineage diversity in valve development.
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