Related Experiment Videos
Peripheral Peters' anomaly: a histopathologic case report.
Journal of Pediatric Ophthalmology and Strabismus
|March 1, 1978
Summary
Congenital corneal leukoma, iris coloboma, and lens subluxation are linked. Abnormal lens-cornea contact during gestation may cause these peripheral corneal defects.
Area of Science:
- Ophthalmology
- Developmental Biology
- Pathology
Background:
- Congenital corneal leukoma is a rare condition affecting vision.
- Iris coloboma and anterior lens subluxation are associated ocular anomalies.
Observation:
- A case of bilateral peripheral corneal leukoma with iris coloboma and anterior lens subluxation was studied.
- Pathologic examination revealed defects in Bowman's membrane, stromal abnormalities, and absence of Descemet's membrane and endothelium at the keratolenticular apposition site.
Findings:
- The corneal changes included stromal thinning, vascularization, and large-diameter collagen fibrils.
- Absence of Bowman's membrane, Descemet's membrane, and endothelium were noted in the affected peripheral cornea.
Implications:
- The findings suggest a dysembryogenesis of the tertiary vitreous as the underlying cause.
- Lens-cornea apposition during early gestation is postulated to result in these peripheral corneal abnormalities.