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Specimen Preparation, Imaging, and Analysis Protocols for Knife-edge Scanning Microscopy
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Gamma Knife Radiosurgery for Meningioma
Tom Flannery1,2, Jonathan Poots3
1Department of Neurosurgery, Royal Victoria Hospital Belfast, Belfast, United Kingdom, t.flannery@qub.ac.uk.
Progress in Neurological Surgery
|May 17, 2019
Summary
Gamma Knife (GK) radiosurgery is a durable treatment for intracranial meningiomas, offering a safe alternative to surgery for various patient groups. Its long-term efficacy makes it suitable for younger patients seeking to avoid open surgical risks.
Area of Science:
- Neurosurgery
- Radiation Oncology
Background:
- Gamma Knife (GK) radiosurgery, first used in 1976, is an established treatment for intracranial meningioma.
- Initially indicated for high-risk patients or those unfit for surgery, its use has expanded.
- Long-term studies demonstrate GK's durability in managing meningiomas.
Purpose of the Study:
- To review current indications for GK in treating intracranial meningioma.
- To discuss the radiobiology of GK for meningioma treatment.
- To analyze patient outcomes following GK for intracranial meningioma.
Main Methods:
- Literature review of studies on Gamma Knife radiosurgery for intracranial meningioma.
- Analysis of treatment indications, radiobiological principles, and patient outcomes.
- Examination of long-term follow-up data.
Main Results:
- GK is effective as an upfront, adjuvant, or salvage treatment for intracranial meningioma.
- The proven durability of GK supports its use in younger patients.
- GK offers an alternative to open surgery, especially for tumors near critical structures.
Conclusions:
- Gamma Knife radiosurgery is a safe and effective treatment option for intracranial meningiomas.
- Long-term efficacy and reduced surgical risks make GK a valuable therapeutic choice.
- Continued research and follow-up will further refine GK's role in meningioma management.
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