Related Experiment Video
Updated: Jan 24, 2026
Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
Published on: March 1, 2024
Cardiovascular Diseases in Psoriasis and Psoriatic Arthritis
Lihi Eder1,2, Amit Dey3,4, Aditya A Joshi3,4
1From the Women's College Research Institute, Women's College Hospital, University of Toronto, Toronto, Ontario, Canada; Laboratory of Inflammation and Cardiometabolic Diseases, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, Maryland, USA; Division of Dermatology and Venereology, Geneva University Hospitals, and Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland; Department of Rheumatology, Uppsala University Hospital, Uppsala, Sweden. Lihi.EDER@wchospital.ca.
Insights
Patients with psoriatic disease face higher cardiovascular risks. Research explores links between psoriasis, vascular inflammation, and atherosclerosis, using advanced imaging and biomarkers to understand shared pathways.
Area of Science:
- Cardiology
- Dermatology
- Rheumatology
Background:
- Psoriatic disease is linked to increased cardiovascular (CV) event risk.
- Understanding the shared mechanisms between psoriasis and CV disease is crucial.
Purpose of the Study:
- To summarize recent research on the association between psoriatic disease and cardiovascular outcomes.
- To highlight advances in imaging, biomarkers, and risk stratification presented at the 2018 GRAPPA meeting.
Main Methods:
- Review of presentations from the 2018 GRAPPA annual meeting.
- Focus on research concerning vascular inflammation, coronary angiogram utility, and CV risk stratification.
- Exploration of shared pathomechanisms between psoriasis and atherosclerosis.
Main Results:
- Psoriasis is associated with significant vascular inflammation.
- Coronary angiogram can be utilized to investigate cardiovascular outcomes in these patients.
- New methods for cardiovascular risk stratification in psoriatic disease patients are emerging.
- Shared pathophysiological pathways link psoriasis and atherosclerosis.
Conclusions:
- Recent research underscores the strong link between psoriatic disease and cardiovascular disease.
- Advances in imaging and biomarkers offer new insights into managing CV risk in psoriasis patients.
- Further investigation into shared pathomechanisms is essential for improved patient outcomes.
Abstract:
Patients with psoriatic disease have an increased risk of developing cardiovascular (CV) events. Recent advances in imaging and biomarker research provide insights into the underlying mechanisms that link these conditions. Here, we summarize recent work in this field that was presented at the July 2018 Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) annual meeting in Toronto, Ontario, Canada. The presentations highlighted recent data about the association between psoriasis and vascular inflammation, the use of coronary angiogram to investigate CV outcomes, new approaches for CV risk stratification, and the shared pathomechanisms of psoriasis and atherosclerosis.
Related Concept Videos
01:27Psychoneuroimmunology: Cardiovascular Disease
A key area of focus in PNI is the relationship between stress and coronary...
01:14Overview of the Cardiovascular System
Heart
The heart is the central pump of the cardiovascular system that circulates blood throughout the body. It comprises two atria receiving the blood and two ventricles pumping blood out of the heart. Their rhythmic contractions, called heartbeats, ensure that blood flow remains continuous.
Blood Vessels
Blood...
01:27Regulation of the Cardiovascular System
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
01:20Exercise and Cardiovascular Response
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
01:29Assessment of the Cardiovascular System II: Inspection
Head and Neck
01:25Assessment of the Cardiovascular System IV: Auscultation
Normal Heart Sounds
S1 (First Heart Sound)-
S1 is made by the closure of the mitral and tricuspid valves (atrioventricular valves), marking the beginning of systole.
S2 (Second Heart Sound)-
S2 is made by the closure of the aortic and pulmonic valves (semilunar valves), marking the end of the systole.