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PAX3 is a biomarker and prognostic factor in melanoma: Database mining
Yong Liu1, Shengnan Cui2, Wenbin Li1
1Department of Dermatology, Shaanxi Provincial Hospital of Traditional Chinese Medicine, Xi'an, Shaanxi 710003, P.R. China.
Oncology Letters
|June 13, 2019
Summary
Paired box 3 (PAX3) is highly expressed in melanoma, particularly in males, and linked to worse patient survival. This suggests PAX3 is a potential prognostic biomarker for melanoma treatment development.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- Paired box 3 (PAX3) is a crucial transcription factor for pigment cell development.
- Its precise role and expression patterns in adult tissues, especially in cancer, require further clarification.
Purpose of the Study:
- To computationally investigate PAX3 expression in melanoma.
- To assess its association with patient survival and other genes.
Main Methods:
- Utilized Oncomine and Cancer Cell Line Encyclopedia for gene expression analysis.
- Performed Kaplan-Meier analysis for survival outcomes.
- Investigated gene associations using Coexpedia.
Main Results:
- PAX3 expression is significantly higher in melanoma tissues than normal tissues.
- Elevated PAX3 expression was observed more in male melanoma patients.
- PAX3 expression correlated positively with SRY-box 10 (SOX10) expression.
- High PAX3 mRNA levels in patients were associated with poorer survival rates.
Conclusions:
- PAX3 may serve as a valuable prognostic biomarker in melanoma.
- Its association with SOX10 warrants further investigation.
- Findings provide a basis for developing novel melanoma therapies targeting PAX3.
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