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Ethosomes for Dermal Administration of Natural Active Molecules
Hiba Natsheh1, Elisa Vettorato1,2, Elka Touitou1
1The Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University Jerusalem, Jerusalem, Israel.
Current Pharmaceutical Design
|July 24, 2019
Summary
Ethosomes, advanced nanovesicular carriers, effectively deliver natural active molecules for treating various skin disorders. Their unique composition ensures enhanced skin penetration, good safety, and minimal irritation for novel dermal therapies.
Area of Science:
- Nanotechnology
- Dermatology
- Pharmaceutics
Background:
- Ethosomes are advanced nanovesicular carriers composed of phospholipids, ethanol, and water.
- Their unique structure, featuring fluid bilayers due to high ethanol concentrations, enhances entrapment of diverse molecules.
- This facilitates deep skin penetration for effective dermal delivery.
Purpose of the Study:
- To review the efficacy of ethosomal formulations containing natural active molecules for treating skin disorders.
- To explore applications in both therapeutic and cosmetic contexts.
- To assess the safety and tolerability profile of ethosomal systems.
Main Methods:
- In vitro studies evaluating ethosome characteristics and drug release.
- In vivo studies using animal models to assess efficacy and skin penetration.
- Clinical studies in humans to confirm therapeutic benefits and safety.
Main Results:
- Ethosomal systems demonstrated successful management of various skin conditions, including bacterial/fungal infections, inflammation, acne, arthritis, and skin cancer.
- Formulations with natural compounds showed promise for cosmetic applications.
- High efficacy was observed alongside a favorable safety profile, with no significant toxicity or irritation.
Conclusions:
- Ethosomes are highly effective nanocarriers for dermal delivery of natural active molecules.
- They offer a promising platform for developing novel, safe, and efficient treatments for a range of skin disorders and cosmetic concerns.
- The favorable safety and efficacy profile supports their advancement into clinical practice.
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