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Anti-endotoxin Properties of Polymyxin B-immobilized Fibers

Tohru Tani1,2, Tomoharu Shimizu3, Masaji Tani3

  • 1Biomedical Innovation Center, Shiga University of Medical Science, Otsu, Shiga, Japan. tan@belle.shiga-med.ac.jp.

Advances in Experimental Medicine and Biology
|August 1, 2019
PubMed

Insights

Polymyxin B hemoperfusion via Toraymyxin effectively removes endotoxin, offering a treatment for endotoxemia and septic shock. This method bypasses systemic toxicity, with potential applications in pulmonary diseases.

Area of Science:

  • Pharmacology
  • Nephrology
  • Critical Care Medicine

Background:

  • Polymyxin B exhibits potent bactericidal activity against Gram-negative bacteria by targeting endotoxin.
  • Systemic polymyxin B use is limited by nephrotoxicity and neurotoxicity.
  • Extracorporeal endotoxin adsorption is a potential therapeutic strategy.

Purpose of the Study:

  • To review the development, clinical use, and efficacy of Toraymyxin, a polymyxin B-based hemoperfusion column.
  • To examine the structure and mechanism of the Toraymyxin column.
  • To discuss the current role and potential new applications of Toraymyxin.

Main Methods:

  • Direct hemoperfusion utilizing polymyxin B immobilized on an insoluble carrier.
  • Clinical application for endotoxemia and septic shock treatment.
  • Review of historical data, clinical use, and efficacy.

Main Results:

  • Toraymyxin selectively binds and removes endotoxin from blood.
  • Approved in Japan since 1994 for endotoxemia and septic shock.
  • Demonstrated efficacy in managing severe sepsis and septic shock.

Conclusions:

  • Toraymyxin provides a safe and effective method for endotoxin removal, mitigating systemic toxicity.
  • Established treatment for endotoxemia and septic shock in Japan.
  • Emerging potential for treating pulmonary diseases warrants further investigation.
Keywords:
EndotoxemiaLipopolysaccharidePolymyxinSeptic shockToraymyxin

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