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Updated: Jan 20, 2026
Factors Influencing Drug Absorption: Physicochemical Parameters
Key Physicochemical Characteristics Influencing ADME Properties of Therapeutic Proteins
Xing Jing1, Yan Hou2, William Hallett2
1U.S. Food and Drug Administration, Office of Clinical Pharmacology, DV II, Silver Spring, MD, USA. xing.jing@fda.hhs.gov.
Abstract:
Therapeutic proteins are a rapidly growing class of drugs in clinical settings. The pharmacokinetics (PK) of therapeutic proteins relies on their absorption, distribution, metabolism, and excretion (ADME) properties. Moreover, the ADME properties of therapeutic proteins are impacted by their physicochemical characteristics. Comprehensive evaluation of these characteristics and their impact on ADME properties are critical to successful drug development. This chapter summarizes all relevant physicochemical characteristics and their effect on ADME properties of therapeutic proteins.
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