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Related Concept Videos

Preparation of Mechanically Stable Self-Assembled Peptides Hydrogels05:24

Preparation of Mechanically Stable Self-Assembled Peptides Hydrogels

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This protocol presents three fast and simple preparation methods that use environmental conditions to trigger the self-assembly of peptides into hydrogels. Additionally, the characterization of peptide hydrogels is described, demonstrating that mechanically stable peptide hydrogels can be formed under these straightforward...
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Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid05:08

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This protocol describes a clinically-applicable means of dissolving hydrophobic compounds in an aqueous environment using combinations of self-assembling peptide and amino acid solutions. Our method resolves a major limitation of hydrophobic therapeutics, which lack safe, efficient means of solubility and delivery methods into clinical...
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Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides07:26

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

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This paper describes the formation of highly ordered peptide-based structures by the spontaneous process of self-assembly. The method utilizes commercially available peptides and common lab equipment. This technique can be applied to a large variety of peptides and may lead to the discovery of new peptide-based...
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Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides09:54

Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides

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A protocol for the synthesis of a 1,2-dithiolane modified peptide and the characterization of the supramolecular structures resulting from the peptide...
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Facile Protocol for the Synthesis of Self-assembling Polyamine-based Peptide Amphiphiles (PPAs) and Related Biomaterials08:55

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The synthesis of polyamine-based peptide amphiphiles (PPAs) is a significant challenge due to the presence of multiple amine nitrogens, which requires judicious use of protecting groups to mask these reactive functionalities. In this paper, we describe a facile method for the preparation of these new class of self-assembling...
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A Fourier Transform Infrared Spectroscopy Technique to Study Peptide Self-Assembly03:04

A Fourier Transform Infrared Spectroscopy Technique to Study Peptide Self-Assembly

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This video demonstrates the self-assembly of amyloid peptides into a beta sheet-rich supramolecular structure using Fourier transform infrared spectroscopy. An infrared beam is passed through a crystal with a high refractive index, and energy absorption across the interface of the crystal and the sample is recorded. The secondary structures of the sample proteins are identified by analyzing their characteristic absorption peaks at specific regions of the infrared spectrum, which aids in...
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Related Experiment Video

Updated: Jan 19, 2026

Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility
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Drug Delivery with Designed Peptide Assemblies.

Matthew J Sis1, Matthew J Webber1

  • 1Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.

Trends in Pharmacological Sciences
|September 9, 2019
PubMed
Summary
This summary is machine-generated.

Designed synthetic peptides self-assemble into functional materials for advanced drug delivery. These peptide assemblies offer smart carriers, targeted delivery, and disease responsiveness, overcoming challenges in therapeutic applications.

Keywords:
bioinspired materialsbiomaterialsdrug deliveryself-assemblysupramolecular chemistry

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Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
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Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
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Related Experiment Videos

Last Updated: Jan 19, 2026

Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility
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Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
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Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
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Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Self-assembling synthetic peptides offer a versatile platform for creating functional materials.
  • Their biological relevance makes them ideal for therapeutic and drug delivery applications.
  • Current advancements include 'smart' carriers responding to disease biomarkers.

Purpose of the Study:

  • To review different peptide self-assembly designs for drug delivery.
  • To highlight the advantages of peptide self-assembly in delivering various therapeutics.
  • To demonstrate advanced functionalities like targeting and disease responsiveness in peptide systems.

Main Methods:

  • Review of literature on peptide self-assembly designs.
  • Analysis of peptide-drug conjugates and their assembly mechanisms.
  • Examination of peptide assemblies' interactions with biological systems.

Main Results:

  • Peptide design enables diverse material forms, from nanostructures to hydrogels.
  • Drug molecules can direct peptide assembly, creating integrated delivery systems.
  • Peptides themselves can possess bioactivity or drug-like functions.

Conclusions:

  • Peptide self-assembly is a powerful strategy for developing sophisticated drug delivery vehicles.
  • Advanced functionalities such as targeting and responsiveness can be engineered into these systems.
  • Significant opportunities and challenges exist for the future of peptide-based therapeutics.