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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Evaluating the Function of the Foot Core System in the Elderly08:25

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The functional core stability of the foot contributes to the human static posture and dynamic activities. This paper proposes a comprehensive evaluation for the function of the foot core system, which combines three subsystems. It may provide increased awareness and multifaceted protocol to explore the foot function among different...
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The most commonly used method for generating large numbers of autologous dendritic cells (DCs) for use in tumor immunotherapy is described. The method uses IL-4 and GM-CSF to differentiate DCs from monocytes. The immature DCs are stimulated to mature and then loaded with antigens before they are injected back into the...
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Evaluating the Function of the Foot Core System in the Elderly
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[Immunotherapy: also in elderly patients ?]

Gaëlle Rhyner Agocs1, Vérène Dougoud-Chauvin1, Daniel Betticher1

  • 1Service d'oncologie médicale, HFR, 1708 Fribourg.

Revue Medicale Suisse
|September 10, 2019
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This summary is machine-generated.

Immunotherapy shows promise in oncology for various cancers. Elderly patients can benefit from immune checkpoint inhibitors, which are effective and well-tolerated despite age-related immune changes.

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Area of Science:

  • Oncology
  • Immunology
  • Geriatrics

Background:

  • Immunotherapy has transformed cancer treatment, improving outcomes for several malignancies.
  • Older adults are increasingly considered for immunotherapy due to its favorable safety profile in younger populations.
  • Immunosenescence, age-related immune system decline, raises concerns about immunotherapy efficacy and toxicity in the elderly.

Purpose of the Study:

  • To review the efficacy and safety of immunotherapy in geriatric cancer patients.
  • To summarize the current knowledge on immunotherapy use in elderly individuals based on large clinical trials.

Main Methods:

  • Review of data from large-scale clinical trials involving immunotherapy.
  • Analysis of efficacy and tolerance outcomes specifically in patients aged 65 and older.

Main Results:

  • Immune checkpoint inhibitors demonstrate significant efficacy in treating various cancers in elderly patients.
  • The safety profile of immune checkpoint inhibitors is favorable in the geriatric population, comparable to younger patients.

Conclusions:

  • Immunotherapy, particularly immune checkpoint inhibitors, is a viable and effective treatment option for elderly cancer patients.
  • Further research and inclusion of geriatric patients in clinical studies are warranted to optimize immunotherapy strategies for this population.